Drying Oven vs. Halogen Moisture Analyzer

Moisture determinations need to be rapidly and reliably carried out, so that any necessary interventions in the production process can be made promptly. Typically, this is done using the loss on drying (LOD) reference method, but this is time consuming and prone to errors. Halogen moisture analyzers (HMAs) are faster, provide results without extra calculations, and are suitable for at-line use.

Moisture affects the quality, shelf life and usability of many products, including pharmaceutical substances, plastics, and foodstuffs. Consequently, monitoring and determination of the moisture content in samples is important. LOD using a drying oven is the reference method for moisture determinations, but the complexity of the handling and calculations involved means that it is time consuming and potentially error-prone. Easy-to-use HMAs offer a new method of moisture determination, delivering direct, comparable results in a fraction of the time.

This white paper compares LOD with HMAs, with practical guidance on:

·         The choice of method

·         How halogen moisture analysis can speed up and simplify analysis

·         Validation of HMA against LOD methods

It also outlines alternative and acceptable comparison approaches based on specific process requirements (tolerances) and statistical analysis of the data obtained.